The effect of prostaglandins and aspirin—an inhibitor of prostaglandin synthesis—on adhesion formation in rats

Abstract

The effect of Intrapentoneal application of prostaglandins E₂ and F_2α and of aspirin, a non-steroidal anti-inflanunatory drug, on the formation of intrapentoneal adhesions was investigated in rats, in view of the main role of the body's reaction in adhesion formation. hitraperitoneal adhesions were induced by inflicting uniform trauma to the uterine serosa. It was demonstrated that prostaglandin E₂ may increase adhesion formation and that intrapentoneal aspirin is able to Inhibit its formation.