Cerebrospinal-Fluid Transaminase Concentrations in Clinical Cerebral Infarctions

Abstract
THE enzyme glutamic oxalacetic transaminase is present in all the tissues of the body except bone. It is found in highest concentration in muscle, heart, brain and liver.1 2 3 LaDue and his co-workers4 5 6 have shown experimentally and clinically that acute destruction of heart and liver tissue increases the transaminase activity of the serum. The determination of this activity has found clinical application in the diagnosis of myocardial infarction.Since the brain is also rich in this enzyme, cerebral infarctions could similarly result in a rise in serum transaminase activity. Moreover, the spinal fluid, being an integral part of the nervous system, . . .