Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat
- 17 May 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 322 (3), 223-226
- https://doi.org/10.1016/0014-5793(93)81574-j
Abstract
A 2‐ to 3‐fold increase of GTP cyclohydrolase I (E.C. 3.5.4.16), the key enzyme of tetrahydrobiopterin biosynthesis from GTP, was observed in cerebellum, remaining brain, liver, spleen, and adrenal gland of rats treated with a single dose of lipopolysaccharide (LPS). This led to increased biopterin levels in tissues but not in plasma. Parallel induction of nitric oxide (NO) synthase was indicated by a 10‐ to 100‐fold increase of plasma nitrate levels 6 and 12 hours after injection of LPS. Furthermore, systolic blood pressure was reduced significantly by 23%. Our results demonstrate induction of tetrahydrobiopterin biosynthesis after LPS treatment in vivo.Keywords
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