HL-A8 and LD-8a in Patients with Myasthenia Gravis
- 1 January 1976
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 7 (1), 39-44
- https://doi.org/10.1111/j.1399-0039.1976.tb01027.x
Abstract
The frequency of HL-A8 in myasthenia gravis is markedly increased in women (60–80%) but not in men. The MLC determinant, LD–8a, is frequently associated with HL–A8. Of the 37 female MS patients, 15 were LD–8a positive (41%), whereas of the males only one of seven was LD–8a positive. The frequency of HL–A8 was 68% in women and 29% in men with the disease. We therefore conclude that the gene which is responsible for the increased susceptibility to myasthenia gravis in women and which is present in the MHS region, is more closely linked to the SD–2 than to the LD–1 locus.This publication has 10 references indexed in Scilit:
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