Cardiac, Renal and Hepatic Hypertrophy in Pyridoxine-Deficient Rats.

Abstract

The wet and dry weights of the heart and kidneys of pyridoxine-deficient rats were significantly heavier (g/100 g body weight) than those of ad lib. and paired-weighed littermate controls. The wet and dry weights of the livers of pyridoxine-deficient rats, although significantly heavier than those of paired-weighed controls, did not differ significantly from those of ad lib. controls. The increased weight of these organs is considered to be a true hypertrophy, and was observed after a period of 55 days. It is felt that this relatively rapid method of inducing hypertrophy of these important organs may prove a useful tool in studies of organ growth and function.