RIBOSOMAL LOCALIZATION OF STREPTOMYCIN SENSITIVITY
- 1 April 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (4), 684-686
- https://doi.org/10.1073/pnas.48.4.684
Abstract
Streptomycin decreased the poly-uridylic-acid-dependent incorporation of C14-labeled phenylalanine into acid-insoluble products in a cell-free system containing ribosomes of streptomycin sensitive Escherichia coli and the supernatant of sensitive or resistant cells. There was no inhibition when the system contained ribosomes of streptomycin-resistant E. coli and supernant of either resistant or sensitive cells. The ribosomes are the site of streptomycin-sensitivity. The genetic locus is part of a ribosome-specific region of the bacterial chromosome.Keywords
This publication has 3 references indexed in Scilit:
- SYNTHETIC POLYNUCLEOTIDES AND THE AMINO ACID CODEProceedings of the National Academy of Sciences, 1961
- Mechanism of Streptomycin Action on Bacteria: A Unitary HypothesisNature, 1961
- Effect of Streptomycin on the Incorporation of Amino-Acids labeled with Carbon-14 into Ribonucleic Acid and Protein in a Cell-free System of a MycobacteriumNature, 1959