SYNERGISM BETWEEN BOVINE SEMINAL PLASMA EXTRACT AND TESTOSTERONE PROPIONATE IN SUPPRESSING SERUM CONCENTRATIONS OF GONADOTROPHINS IN ACUTELY CASTRATED RATS: A ROLE FOR INHIBIN
- 1 August 1980
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 86 (2), 349-355
- https://doi.org/10.1677/joe.0.0860349
Abstract
The rise in concentrations of FSH and LH in serum seen 24 h after castration was suppressed by the administration of an extract of bull seminal plasma or testosterone propionate at the time of castration. Whereas testosterone propionate preferentially suppressed LH, the seminal plasma extract suppressed FSH and LH equally. Small doses of bull seminal plasma extract and testosterone, that had little effect separately, acted synergistically to suppress levels of FSH and LH to those found in intact animals, while combinations of larger doses had little further effect. This selective interaction suggests how inhibin and testosterone might together regulate concentrations of FSH and LH in the blood of the male rat.This publication has 11 references indexed in Scilit:
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