Effect of a Minimal Fluoride Diet on Rats.

Abstract

Summary The feeding of a minimal fluoride (< 0.005 ppm F) diet for a 10-week period to weanling rats demonstrated significantly lower levels of bone fluoride compared to the control group receiving the minimal diet plus 2 ppm fluorine. Serum and liver enzymes activities were determined, and the only significant differences noted were an increase in serum isocitric dehydrogenase and a decrease in activity of this enzyme in the liver.