Purification and Reconstitution of the Periodic Fibril and Unit Structure of Human Amyloid
- 14 October 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 154 (3746), 271-272
- https://doi.org/10.1126/science.154.3746.271
Abstract
Extraction with alkaline sodium glycinate of the periodic fibril and unit structure of human amyloid and subsequent acidification of the extract provided a method for the purification as well as for the reconstitution of the periodic rod and of the unit structure. Guanidine completely solubilized and irreversibly dissociated both the rod and the unit structure of the human amyloid fibril.This publication has 3 references indexed in Scilit:
- The ultrastructure of human amyloid as revealed by the negative staining techniqueJournal of Ultrastructure Research, 1966
- Solubility characteristics of isolated amyloid fibrilsBiochimica et Biophysica Acta (BBA) - General Subjects, 1965
- Structure of Amyloid Fibrils after Negative Staining and High-resolution Electron MicroscopyNature, 1965