Transient tectogeniculate projections in neonatal kittens: An autoradiographic study

Abstract

By using anterograde transport autoradiography, the present experiments demonstrated that the pattern of tectogeniculate projections in young (birth–14 postnatal days) kittens is strikingly different from that present in adult cats. Rather than being confined to the ventral C laminae, the neonatal projection extended across all layers of the lateral geniculate nucleus. This projection, like that in the adult cat, originates from cells in superficial laminae and is visuotopically organized. Thus, labeling only a portion of the superior colliculus with tritiated leucine produced a topographically appropriate strip of labeling in the ipsilateral lateral geniculate nucleus that encompassed all laminae and was especially dense in all interlaminar zones. Transported label also invaded the medial interlaminar nucleus (MIN). The loss of tectogeniculate projections in the neonate from MIN and the dorsal laminae and interlaminar zones of the lateral geniculate nucleus does not appear to begin until 1–2 weeks postnatal. Once initiated, however, the process is nearly completed by 21 days postnatal. It is not yet known whether the loss of these “anomalous” projections is due to the pruning of axonal collaterals, cell death, or a combination of the two processes. However, by comparing these data with those from other laboratories, it does appear that the loss of tectogeniculate projections depends on the presence of the two eyes and may reflect the differential laminar distribution of W‐, X‐, and Y‐cell types. The protracted postnatal anatomical maturation of tectogeniculate projections differs substantially from the earlier maturing patterns apparent in all other tectofugal pathways.