The effect of chemonucleolysis on serum keratan sulfate levels in humans
Open Access
- 1 January 1989
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 32 (1), 100-104
- https://doi.org/10.1002/anr.1780320118
Abstract
Sensitive measurements of serum keratan sulfate (KS), a glycosaminoglycan found in large quantities in the proteoglycans of human cartilage, can be obtained using an enzyme-linked immunosorbent-inhibition assay. Patients who are undergoing chemonucleolysis (CN) provide a clinical opportunity to monitor the large-scale proteolytic degradation of cartilage. By measuring serum KS levels both pre- and post-CN, we have demonstrated that serum KS levels rise predictably after CN, in a manner that reflects major catabolic events of cartilage.This publication has 12 references indexed in Scilit:
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