THE INABILITY OF A DIABETOGENIC VIRUS TO INDUCE DIABETES MELLITUS IN ATHYMIC (NUDE) MICE
- 15 August 2009
- journal article
- research article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Section C Immunology
- Vol. 84C (4), 299-303
- https://doi.org/10.1111/j.1699-0463.1976.tb00033.x
Abstract
The effect of a known diabetogenic M-strain encephalomyocarditis (EMC)-virus in athymic nude mice (lacking the thymus-dependent lymphocyte system), and in heterozygous littermates and homozygous normal mice of the background strain (C57/B16) was investigated. By 3 wk, 4 of 4 surviving virus-inoculated littermates and 9 of 9 inoculated normal mice developed diabetes mellitus; none of the 7 surviving virus-inoculated nude mice became diabetic. Virus was isolated from all inoculated animals, including non-diabetic nude mice. It is probably the response of the thymus-dependent lymphocyte system evoked by the virus rather than the virus itself that leads to damage of the insulin producing cell.Keywords
This publication has 6 references indexed in Scilit:
- Glucose Intolerance and Islet Damage in Mice Immunized with Homologous Endocrine Pancreas - A Preliminary CommunicationHormone and Metabolic Research, 1974
- Antipancreatic Cellular Hypersensitivity in Diabetes MellitusDiabetes, 1971
- Viral Antibodies in Diabetes MellitusBMJ, 1969
- Diabetes Mellitus: Induction in Mice by Encephalomyocarditis VirusScience, 1968
- Absence of Thymus in a Mouse MutantNature, 1968
- Pathologic Anatomy of the Pancreas in Juvenile Diabetes MellitusDiabetes, 1965