Clinical Evaluation of Carcinoembryonic Antigen Test
- 1 August 1973
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 107 (2), 266-274
- https://doi.org/10.1001/archsurg.1973.01350200128027
Abstract
We have measured plasma levels of carcinoembryonic antigen (CEA) in 259 patients with a variety of cancers, 266 patients with noncancerous disease, and 176 healthy subjects. Sixty-six of 73 patients with malignant tumors of the gastrointestinal tract had elevated (> 2.5 ng/ml) CEA levels. There was no correlation between CEA level and extent of disease. Inconsistencies were noted between clinical status and CEA levels during follow-up of seven of 26 patients 3 to 96 months postoperatively. Elevated levels of CEA were detected in 117 of 186 patients with nonentodermally derived tumors, 83 of 183 patients with noncancerous disease, and 19 of 176 healthy individuals. The lack of specificity and sensitivity of the CEA test limit its usefulness as a screening procedure. Our data also suggest that it may have limited value in detecting recurrence.This publication has 5 references indexed in Scilit:
- Tumor associated antigen in the chemotherapy of solid tumorsJournal of Surgical Oncology, 1972
- General principles of radioimmunoassayClinica Chimica Acta; International Journal of Clinical Chemistry, 1968
- PHYSICOCHEMICAL STUDIES OF THE CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEMThe Journal of Experimental Medicine, 1968
- SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEMThe Journal of Experimental Medicine, 1965
- The classification of cancer of the rectumThe Journal of Pathology and Bacteriology, 1932