Effect of Idebenone (CV-2619) on Memory Impairment Observed in Passive Avoidance Task in Rats with Cerebral Embolization
Open Access
- 1 January 1985
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 37 (3), 300-302
- https://doi.org/10.1254/jjp.37.300
Abstract
Effect of idebenone (CV-2619) on memory impairment was studied in rats with cerebral embolization. The cerebral embolization, produced by injecting 2000 microspheres into the internal carotid artery, caused a significant impairment in passive avoidance response. Repeated administrations of idebenone (30 mg/kg/day, i.p.), partially but significantly improved the impairment of the passive avoidance response in the embolized rats. The results suggest that the repeated administration of idebenone exerts an ameliorating effect on memory impairment induced by cerebral embolization.Keywords
This publication has 4 references indexed in Scilit:
- Inhibition of lipid peroxidation by a novel compound, idebenone (CV-2619).The Japanese Journal of Pharmacology, 1984
- Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats.The Japanese Journal of Pharmacology, 1984
- Effect of lysine vasopressin on pentylenetetrazol-induced retrograde amnesia in ratsPharmacology Biochemistry and Behavior, 1977
- The effects of ACTH- and vasopressin-analogues on CO2-induced retrograde amnesia in ratsPhysiology & Behavior, 1974