Hypertelorism is probably more common than reports indicate, and many readers may recall characteristic facies in their clinical experience. Reported cases are, however, rare. I have found only thirteen cases in the literature and hence am reporting four recently observed in the pediatric service of the University of California. In 1890, Fridolin1of St. Petersburg described a plagiocephalic skull that was probably a unilateral hypertelorism. However, the identity of this condition was not established until 1924, when Grieg2of Edinburgh first described the complete clinical and pathologic picture to which he applied the term hypertelorism. Subsequent cases have been reported from Great Britain, though the tenth and eleventh cases were reported from France and the United States, respectively. Hypertelorism is a developmental, congenital anomaly of the lesser wings of the sphenoid bone. Owing to the excess growth of these wings the orbits are widely separated and the horizontal