Propofol administration reduces hippocampal neuronal damage induced by kainic acid in rats.

Abstract

The goal of this study was to determine whether propofol has protective effect against kainic acid (KA)I. ndu~ed excftotoxicity. Administration of propofol (25 mg kg-⁷ i.p.) was done 2 h, before KA (10 mg kg-¹ I.P.), Immedlatelyafte:1 and 2h, 4h, 6h, and 12 h afte~ the KAI and twice daily for an additional three days. Neuronal cell death In CA 1 an.d .CA3 subsector of hIppocampus was evaluated quantitatively four days after KA. The KA and propofol-Injected rats had a greater number of surviving neuronal cells than did KA (and vehicle)-Injected rats. Our results suggest that propofol holds potential for the protection of neuronal cells agaInst KA-induced excitotoxicity. [Neural Res 1999; 21: 225-228]