Amphidinolide W, a New 12-Membered Macrolide from Dinoflagellate Amphidinium sp.
- 5 January 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 67 (3), 1020-1023
- https://doi.org/10.1021/jo016089o
Abstract
A new cytotoxic 12-membered macrolide, amphidinolide W (1), has been isolated from a marine dinoflagellate Amphidinium sp., and the structure was elucidated by spectroscopic data including 13C−13C INADEQUATE correlations for its 13C-enriched sample. The absolute stereochemistry of 1 was assigned by combination of J-based configuration analysis and modified Mosher method. Amphidinolide W (1) is the first macrolide without an exomethylene unit among all amphidinolides obtained so far.Keywords
This publication has 6 references indexed in Scilit:
- Colopsinols D and E, New Polyhydroxyl Linear Carbon Chain Compounds from Marine Dinoflagellate Amphidinium sp.CHEMICAL & PHARMACEUTICAL BULLETIN, 2000
- Stereochemical Determination of Acyclic Structures Based on Carbon−Proton Spin-Coupling Constants. A Method of Configuration Analysis for Natural ProductsThe Journal of Organic Chemistry, 1999
- HETLOC, an Efficient Method for Determining Heteronuclear Long‐Range Couplings with Heteronuclei in Natural AbundanceAngewandte Chemie International Edition in English, 1991
- Regioselective synthesis of 1-formylcyclohexenes by one-carbon homologationThe Journal of Organic Chemistry, 1991
- High-field FT NMR application of Mosher's method. The absolute configurations of marine terpenoidsJournal of the American Chemical Society, 1991
- Heteronuclear filters in two-dimensional [1H, 1H]-NMR spectroscopy: combined use with isotope labelling for studies of macromolecular conformation and intermolecular interactionsQuarterly Reviews of Biophysics, 1990