THE SIGNS and symptoms of the uncommon condition known as "pulseless disease" (aortic arch syndrome) are dependent on the location of the vascular occlusions and the adequacy of the collateral circulation.1The "subclavian steal syndrome" and signs of carotid artery insufficiency may be appreciated if the appropriate vessels are involved. In addition, claudication of muscles supplied by involved blood vessels may be noted.2,3 A case of a young woman with Hodgkin's disease who developed "pulseless disease" is presented. A possible relationship to radiotherapy given for the treatment of Hodgkin's disease is suggested. Report of a Case A 21-year-old, married, white secretary was referred to the Tumor Service of the US Public Health Service Hospital, Baltimore, on Oct 14, 1953. A chest film taken elsewhere in March 1953 demonstrated mediastinal widening. Supraclavicular lymphadenopathy was detected in October 1953; a lymph node biopsy was diagnostic of Hodgkin's granuloma. Upper extremity