ENDOCRINE FACTORS DETERMINING THE RATE OF ACCUMULATION OF ENDOMETRIAL SECRETIONS IN EXPERIMENTAL HYDROUTERI OF MICE1

Abstract

Endocrine factors were studied which influence rate of accumulation of endometrial secretions (uterone) in experimental hydrouteri of mice following ligation of the cervix. Estrus at the time of ligation as well as small amounts of estrogen given at the time of ligation favor the accumulation of uterone as does administration of estrogen or progesterone (in pellets) during hydrouterus formation. Diestrus at the time of ligation prevents subsequent hydrouterus formation. Testosterone inhibits endometrial secretion when given at the time of cervical ligation and causes regression of hydrouteri once they have been formed. These androgen effects can be prevented by estrogen or cortisone.