A STUDY OF PROGESTERONE INACTIVATION BY THE LIVER AFTER INTRAPORTAL ADMINISTRATION

Abstract

Progesterone in microcrystals was injd. into infantile rabbits in the Clauberg test by the subcut. route and by injn. into the portal vein. The progestational activity of progesterone applied intraportally was inferior in low amts. (0.5-1 mg.). Doses above 2 mg. were fully active. Some inactivation of progesterone by the liver in vivo seems to occur.