Topical methoxsalen and blacklight in the treatment of psoriasis
- 1 March 1977
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 113 (3), 292-296
- https://doi.org/10.1001/archderm.113.3.292
Abstract
Patients (30) with recalcitrant psoriasis were treated with topical methoxsalen and blacklight (UVA). A 1% concentration either in an acetone, alcohol, propylene glycol vehicle, or hydrophilic ointment, USP, applied 2 h before light exposure was highly effective. Twelve patients were completely cleared and 9 were markedly improved in 3-5 wk. Plaque-type and guttate psoriasis responded best while exfoliative psoriasis benefitted less. Maintenance of a phototoxic reaction in the lesion was necessary for total resolution. Topical methoxsalen and blacklight is feasible for outpatient treatment of plaque-type psoriasis of limited extent.This publication has 2 references indexed in Scilit:
- The Effect of Structural Alterations on the Erythemal Activity of Furocoumarins: Psoralens**From the Departments of Dermatology and Biochemistry, University of Oregon Medical School, Portland, Oregon and the Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan.Journal of Investigative Dermatology, 1960
- Part V: Clinical Applications of Psoralens, and Related Materials: Modification of Ultraviolet Carcinogenesis by Photoactive Agents1Journal of Investigative Dermatology, 1959