Mitochondrial genetics, circular DNA and the mechanism of thepetitemutation in yeast
- 1 August 1974
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 24 (1), 43-57
- https://doi.org/10.1017/s0016672300015068
Abstract
SUMMARY: We propose a general hypothesis involving properties of circular DNA which can explain such phenomena as thepetitemutation, suppressiveness, and the polarity observed in mitochondrial recombination in the yeastSaccharomyces cerevisiae. This hypothesis involves excision and insertion events between circular DNA molecules as well as structural rearrangements in the DNA generated by these events. The special properties of circular DNA have been considered in analysing recombination, and a number of results are obtained which are not intuitively apparent.This hypothesis can be applied to any situation involving circular DNA such as bacterial plasmids and cytoplasmic circular DNAs, where the opportunity exists for recombination and rearrangement events.Keywords
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