Effect of Infused Ketone Bodies on Glucose Utilization in the Dog*

Abstract

Ketone body infusion into the intact fasting dog produces prompt hypoglycemia and improves glucose tolerance. When hyperglycemia is established by the constant infusion of glucose, acetoacetate or [beta]-hydroxybutyrate promotes hyperglycemia. This effect is consistent with an inhibition of peripheral glucose utilization, in accord with the findings of others using isolated muscle preparations. Such an inhibition of peripheral uptake may play a role in the faulty glucose utilization seen in certain clinical disorders in which increased fat mobilization occurs.