Suppression of 17-Hydroxycorticosteroids in Plasma and Urine by Single and Divided Doses of Triamcinolone

Abstract

PROLONGED suppression of the pituitary-adrenal axis after therapy with anti-inflammatory steroids, with resultant decrease in adrenocortical secretion and impaired response to stress, has been the subject of numerous published articles.^{1 2 3} Di-Raimondo and Forsham,^{4 , 5} however, reported that less suppression occurs when the total dose of corticosteroid is administered in the morning.In this study we compared the extent and duration of suppression of adrenocortical secretion by 8 mg. of triamcinolone given as a single dose in the morning and by the same amount given in 4 divided doses throughout the day.Materials and MethodsIn a pilot study daily morning doses . . .