Distractability under the Influence of an Acth 4-9 Derivative
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in International Journal of Neuroscience
- Vol. 22 (1-2), 21-36
- https://doi.org/10.3109/00207459308987382
Abstract
Event-related brain potentials, autonomic responses, and response latency under distraction conditions served to investigate the effects of an ACTH 4-9 derivative (ORG 2766) on attention. Male volunteers (45) received either 40 mg ORG 2766 or placebo in a double-blind setting. Two-stimulus trials with acoustic warning signal (S1) and acoustic S2 which had to be interrupted by immediate button press, preceded trials with distraction during the warning interval in 50% of the trials. A final period without distraction served to test for rebound effects. A reduction in early CNV was found in placebo subjects under distraction, while subjects under ORG 2766 showed no reduced early negativity, but increased late negativity under this condition. Peptide subjects differed from controls in evoked potential components, showing enhanced N1 and P3 amplitudes. Activity in the alpha band was elevated. Postexperimental systolic blood pressure was raised by 15 mm Hg under ORG 2766. Results are in agreement with previous findings and suggest ORG 2766 effects on distraction resistance and attention fixation.This publication has 15 references indexed in Scilit:
- Principal component analysis of slow brain potentials during six second anticipation intervalsBiological Psychology, 1981
- Effect of an ACTH 4–9 analog on human cortical evoked potentials in a two-stimulus reaction time paradigmPsychoneuroendocrinology, 1981
- Effect of an ACTH 4–9 analog on human cortical evoked potentials in a constant foreperiod reaction time paradigmPsychoneuroendocrinology, 1981
- Modulatory Actions of NeurotransmittersAnnual Review of Neuroscience, 1979
- MSH/ACTH4–10 and task-induced increase in tendon reflexes and heart ratePharmacology Biochemistry and Behavior, 1978
- Physiologische PsychologiePublished by Springer Nature ,1975
- Polypeptide influences on attention, memory and anxiety in manPharmacology Biochemistry and Behavior, 1974
- Contingent negative variation (CNV) and psychological processes in man.Psychological Bulletin, 1972
- Effects of ACTH on EEG Habituation in Human SubjectsPublished by Elsevier ,1970
- The two-arousal hypothesis: Reticular formation and limbic system.Psychological Review, 1968