Comparison of Natural and Synthetic Prostaglandins on Gastric and Pancreatic Secretions and Peptic Ulcer Formation in Conscious Cats

Abstract

In conscious cats with chronic gastric and pancreatic fistulas, the natural prostaglandins (PGs) of the E (PGE₁ and PGE₂) and F (PGF_1α and PGF_2α) series and synthetic 15-methyl analog of PGE₂, 15(S) 15-methyl-PGE₂methylester were compared with regard to their action on gastric and pancreatic secretions and peptic ulcer formation. This study indicates that in comparison with natural PGs, the synthetic 15-methyl analog of PGE₂ is a more potent inhibitor of gastric secretion regardless of the route of administration and the mode of gastric stimulation. It more effectively prevents the formation of peptic ulcers in conscious cats.