Mutant fibronectin gene in skin fibroblasts of sclerotic lesions from patients with progressive systemic sclerosis
Open Access
- 1 March 1989
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 32 (3), 247-250
- https://doi.org/10.1002/anr.1780320303
Abstract
A mutant fibronectin gene was identified in skin fibroblasts obtained from sclerotic lesions of 7 patients with progressive systemic sclerosis. We found 2 point mutations adjacent to the cell-attachment tetrapeptide DNA sequence in the cell-binding domain of the fibronectin gene. This observation suggests that the mutant fibronectin is related to an integral component of sclerotic pathogenesis through abnormal cellular interactions.This publication has 15 references indexed in Scilit:
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