The primary structure of the fourth component of human complement (C4)-C-terminal peptides
- 1 January 1985
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 5 (10-11), 913-921
- https://doi.org/10.1007/bf01119904
Abstract
C-terminal CNBr peptides of the three polypeptide chains of C4 were obtained and sequenced. These results supplement previously obtained data, notably the protein sequence derived from cDNA sequencing of pro-C4 (Belt KT, Carroll MC & Porter RR (1984) Cell36, 907–914) and the N-terminal sequences of the three polypeptides (Gigli I, von Zabern I & Porter RR (1977) Biochem. J.165, 439–446), to define the complete primary structure of the plasma form of C4. The β (656 residues), α (748 residues), and γ (291 residues) chains are found in positions 1–656, 661–1408, and 1435–1725 in the pro-C4 molecule.This publication has 32 references indexed in Scilit:
- Identification of the peptide bond cleaved during activation of human ClrFEBS Letters, 1985
- The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAsNucleic Acids Research, 1985
- Polymorphism of human complement component C4Immunogenetics, 1985
- The structural basis of the multiple forms of human complement component C4Cell, 1984
- A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor BNature, 1984
- Complete amino acid sequence of the catalytic chain of human complement subcomponent C.hivin.1rBiochemistry, 1983
- Identification and partial characterization of the secreted form of the fourth component of human complement: evidence that it is different from major plasma form.Proceedings of the National Academy of Sciences, 1983
- Amino acid sequence around the thiol and reactive acyl groups of human complement component C4Biochemical Journal, 1981
- The binding of human complement component C4 to antibody-antigen aggregatesBiochemical Journal, 1980
- Purification and structural analysis of the fourth component of human complementBiochemistry, 1977