Emulsion Formulations: Study of the Influence of Parameters with Experimental Designs

Abstract

Parameters of formulation of emulsions were performed by the aid of experimental designs. The aim of the work was to investigate five factors at two levels: temperature of manufacture, time of phase introduction, rate of homogenization, mode of cooling, and operators. The study of the flow behavior of the emulsions corresponds to the quantitive response. This work allowed us to show the dominating influence of the factor “mode of cooling”. The progressive cooling at room temperature gives a better stability than the brutal cooling with a water bath corresponding to a shorter homogenization. A further aim was to study the influence of an additional factor: the nature of the sulfactant with the best mode of cooling, progressive cooling. In that case, we can conclude that the main factor, the nature of the surfactant, influences the response.