Identification of Neutralizing Epitopes within Structural Domain III of the West Nile Virus Envelope Protein
Open Access
- 15 December 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (24), 13097-13100
- https://doi.org/10.1128/jvi.76.24.13097-13100.2002
Abstract
Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330, and E332.Keywords
This publication has 17 references indexed in Scilit:
- West Nile Virus Strains Differ in Mouse Neurovirulence and Binding to Mouse or Human Brain Membrane Receptor PreparationsAnnals of the New York Academy of Sciences, 2001
- Identification of epitopes on the envelope (E) protein of dengue 2 and dengue 3 viruses using monoclonal antibodiesArchiv für die gesamte Virusforschung, 2001
- Monoclonal Antibodies That Bind to Domain III of Dengue Virus E Glycoprotein Are the Most Efficient Blockers of Virus Adsorption to Vero CellsJournal of Virology, 2001
- Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: insight into the neutralization mechanismJournal of General Virology, 2001
- Amino Acid Substitution(s) in the Stem-Anchor Region of Langat Virus Envelope Protein Attenuates Mouse NeurovirulenceVirology, 2001
- Biophysical Characterization and Vector-Specific Antagonist Activity of Domain III of the Tick-Borne Flavivirus Envelope ProteinJournal of Virology, 2001
- Attenuation of Tick-Borne Encephalitis Virus by Structure-Based Site-Specific Mutagenesis of a Putative Flavivirus Receptor Binding SiteJournal of Virology, 2000
- Substitutions at the Putative Receptor-Binding Site of an Encephalitic Flavivirus Alter Virulence and Host Cell Tropism and Reveal a Role for Glycosaminoglycans in EntryJournal of Virology, 2000
- Origin of the West Nile Virus Responsible for an Outbreak of Encephalitis in the Northeastern United StatesScience, 1999
- West Nile virus envelope proteins: nucleotide sequence analysis of strains differing in mouse neuroinvasiveness.Journal of General Virology, 1998