Colonization resistance of the digestive tract and the spread of bacteria to the lymphatic organs in mice
- 1 June 1972
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 70 (2), 335-342
- https://doi.org/10.1017/s0022172400022385
Abstract
SUMMARY: After oral contamination of conventional mice with high doses ofEscherichia coli, Klebsiella pneumoniaeorPseudomonas aeruginosathe contaminant was recovered in abnormally high concentrations from the duodenum and caecum during the first few days. In this initial colonization phase, evidence of spread was obtained by culturing the cervical and mesenteric lymph nodes and spleen. Longer after contamination the intestinal concentration decreased to normal and spread stopped. In orally antibiotic-treated mice, the situation seen during the initial colonization phase in conventional mice occurred after a much lower oral contamination dose and persisted during the entire observation period of 2 weeks.Keywords
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