The role of cellular degeneration in the normal development of (rat) otocyst
- 1 September 1976
- journal article
- Published by Wiley in The Laryngoscope
- Vol. 86 (9), 1413-1425
- https://doi.org/10.1288/00005537-197609000-00015
Abstract
From day 12 to 16 of gestation a highly circumscribed zone of cellular degeneration has been observed in the otocyst of more than 50 normal rats. This zone appears to be produced by selective or programmed cell death, and results in the elimination of unneeded cellular elements. That cells in this zone are also selectively destroying subcellular organelles as a first step in specialization is also discussed. Programmed cellular death has long been known in other systems and is often an obligatory companion to cellular specialization. The ear now joins the long list of organs which demonstrate this phenomenon.Keywords
This publication has 9 references indexed in Scilit:
- CELL DEATH IN THE EMBRYONIC CHICK SPINAL CORDThe Journal of cell biology, 1974
- Cell death in the normal neonatal rat adrenal cortexThe Journal of Pathology, 1973
- A radioautographic study of deoxyribonucleic acid synthesis in embryonic rat palatal shelf epithelium with reference to the concept of programmed cell deathArchives of Oral Biology, 1973
- Cell kinetics of the 11 and 12‐day mouse otocystsThe Laryngoscope, 1971
- Cell necrosis in the central nervous system of normal rat fetusesNeurology, 1967
- Death in Embryonic SystemsScience, 1966
- Cell Death in MorphogenesisPublished by Elsevier ,1966
- Sex Differences in Pituitary Gonadotrophic Function of Protein-Deficient RatsEndocrinology, 1964
- CELL DEATHS IN NORMAL VERTEBRATE ONTOGENYBiological Reviews, 1951