Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance.
Open Access
- 1 July 1976
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 144 (1), 293-297
- https://doi.org/10.1084/jem.144.1.293
Abstract
Adult cells required approximately 1000-fold more trinitrophenyl-human .gamma.-globulin to be rendered tolerant than did cells from 9- to 12-day-old neonates. The potential effects of suppressor T [thymus-derived] cells were excluded by pretreating the cultured B cells with anti-Thy-1 and C [complement], and the helper T cells with anti-Ly-2.2 and C''. The possible role of cell surface immunoglobulin isotypes in contributing to this observed difference is discussed.This publication has 20 references indexed in Scilit:
- Ontogeny of the antibody‐forming cell line in mice. I. Kinetics of appearance of mature B cellsEuropean Journal of Immunology, 1975
- Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. Possible implications for B-cell tolerance to self.The Journal of Experimental Medicine, 1975
- The characterization fo the B-cell repertoire specific for the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice.The Journal of Experimental Medicine, 1975
- Neonatal Tolerance Induced by Antibody against Antigen-Specific ReceptorScience, 1974
- ONTOGENY OF B LYMPHOCYTESThe Journal of Experimental Medicine, 1974
- In vitro induction of specific unresponsiveness against the 2,4,6-trinitrophenyl determinant. I. The induction of unresponsiveness.1974
- CHARACTERIZATION OF SPLENIC LYMPHOID CELLS IN FETAL AND NEWBORN MICEThe Journal of Experimental Medicine, 1973
- Differential stimulation of precursor cells and carrier-specific thymus-derived cell activity in the in vivo reponse to heterologous erythrocytes in mice.1972
- Brain-associated Θ antigen: Reactivity of rabbit anti-mouse brain with mouse lymphoid cellsCellular Immunology, 1971
- An in Vitro Primary Immune Response to 2, 4, 6-Trinitrophenyl Substituted Erythrocytes: Response against Carrier and HaptenThe Journal of Immunology, 1970