The Antimalarial Trioxaquine DU1301 Alkylates Heme in Malaria-Infected Mice
- 1 August 2008
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 52 (8), 2966-2969
- https://doi.org/10.1128/aac.00165-08
Abstract
The in vivo alkylation of heme by the antimalarial trioxaquine DU1301 afforded covalent heme-drug adducts that were detected in the spleens of Plasmodium sp.-infected mice. This result indicates that the alkylation capacities of trioxaquines in mammals infected with Plasmodium strains are similar to that of artemisinin, a natural antimalarial trioxane-containing drug.Keywords
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