Substituted Dihydroxybenzoic Acids as Possible Anti-Inflammatory Agents
- 1 September 1963
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 15 (1), 633-638
- https://doi.org/10.1111/j.2042-7158.1963.tb12853.x
Abstract
A series of substituted dihydroxybenzoic acids was prepared and examined for anti-inflammatory activity. The compounds which showed activity were derived from γ-resorcylic acid. The introduction of a halogen atom at positions 3 and 5 and a benzyl or methyl group at position 4 gave marked activity but also increased toxicity.Keywords
This publication has 11 references indexed in Scilit:
- Effect of Pregnancy and Lactation on Granuloma Tissue Formation and Joint Permeability in Rats.Experimental Biology and Medicine, 1953
- Phenolic Compounds in the Treatment of Rheumatic FeverCirculation, 1953
- Sodium -Resorcylate in Rheumatic FeverBMJ, 1951
- Zur Frage des Mechanismus der Hemmung des Bindegewebswachstums durch CortisoneCellular and Molecular Life Sciences, 1950
- 61. Synthesis of compounds related to mould metabolic products. Part I. 3 : 5-Dihydroxy-2-formylbenzoic acid and 3 : 5-dihydroxyphthalic acidJournal of the Chemical Society, 1942
- Orientation in the Benzene Ring. The Preparation of 5-Chloro-β-resorcylic Acid1Journal of the American Chemical Society, 1935
- Zur Kenntnis der ResorzylalkoholeArchiv der Pharmazie, 1932
- CCXCIII.—A synthesis of pyrylium salts of anthocyanidin type. Part XIVJournal of the Chemical Society, 1927
- Über die Carbomethoxy‐Derivate der Phenol‐carbonsäuren und ihre Verwendung für Synthesen. VIII. Derivate der Orsellinsäure und α‐ResorcylsäureEuropean Journal of Inorganic Chemistry, 1913