A patient with iron storage disease secondary to transfusions for temporary aplastic anemia was found to have hypoparathyroidism. The patient had minimal signs or symptoms of his marked hypocalcemia. The development of such an endocrine disturbance has not been reported previously in iron storage disease. The appearance of parathyroid dysfunction in this patient may be related to his long survival after transfusional iron overload (at least 11 years before the onset of hypoparathyroidism).