A study of the effect of overfeeding on the protein metabolism of man

Abstract

The superimposition of a liter of raw or boiled milk on a diet adequate for the maintenance of body weight and N equilibrium brought about an increase in weight and a marked retention of N and S but not of Ca. Comparison of the N retentions revealed no real difference in the metabolic fate of the added proteins of raw or boiled milk, whether administered for 1 day or 8 consecutive days. The addition of equivalent Na caseinate to the diet of 1 subject resulted in a definite but much less marked storage of N. The superimposition of beef + lactose + butter equivalent to a liter of milk also effected a definite saving of food N which was still in evidence even after 15 days of surfeit. Soya flour + lactose + butter appeared to have a similar effect though the period of observation was short. On resumption of basal conditions the retained N was apparently eliminated at a slow rate.