Cyclosporin in rheumatoid arthritis: a double blind, placebo controlled study in 52 patients.
Open Access
- 1 February 1988
- journal article
- research article
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 47 (2), 127-133
- https://doi.org/10.1136/ard.47.2.127
Abstract
The efficacy and safety of cyclosporin A (CyA) for patients with rheumatoid arthritis were assessed in a four month double blind, placebo controlled study using an initial dosage of 5 mg/kg daily. Six patients withdrew from the study (two in the placebo group because of inefficacy of treatment and four in the CyA group because of side effects). These six patients were considered therapeutic failures. At the end of the trial the study treatment was considered as good or very good by 14 out of the 26 CyA group patients and by only two out of the 26 placebo group patients. Moreover, in the CyA group significant improvement was observed in five of the seven clinical assessment criteria. Clinical improvement was correlated with a decrease in C reactive protein, alpha 1 glycoprotein levels, and platelet count but not with erythrocyte sedimentation rate or rheumatoid factor titres. Renal toxicity (13 cases) remained the major problem in the management of these patients. This study shows that CyA is effective in active rheumatoid arthritis but requires close monitoring for toxicity.This publication has 19 references indexed in Scilit:
- Cyclosporin a in rheumatoid arthritis: preliminary clinical results of an open trialArthritis & Rheumatism, 1987
- Sulphasalazine in ankylosing spondylitis: a double blind controlled study in 60 patients.BMJ, 1986
- Cyclosporin treatment for rheumatoid arthritis: a placebo controlled, double blind, multicentre study.Annals Of The Rheumatic Diseases, 1986
- RANITIDINE, CIMETIDINE, AND THE CYCLOSPORINE-TREATED RECIPIENTTransplantation, 1986
- Rapidly progressive glomerulonephritis with glomerular crescent formation in rheumatoid arthritisClinical Rheumatology, 1985
- Side effects of systemic cyclosporine in patients not undergoing transplantationAmerican Journal Of Medicine, 1984
- Tiopronin (n-[2-mercaptopropionyl] glycin) in rheumatoid arthritisArthritis & Rheumatism, 1982
- Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2European Journal of Immunology, 1981
- Evaluation Of A Functional Index In Rheumatoid ArthritisScandinavian Journal of Rheumatology, 1973
- Diagnostic Criteria for Rheumatoid Arthritis: 1958 RevisionAnnals Of The Rheumatic Diseases, 1959