Relation of Mammotropes to Mammary Tumors. IV. Development of Highly Hormone Dependent Mammary Tumors.

Abstract

Highly mammotropic hormone dependent mammary adenocarcinomas were induced in rats by a combined treatment of a subthreshold dose of 3-methylcholanthrene and grafts of a functional mammotropic tumor. Growth of these mammary tumors was dependent upon the continuation of stimulation by the mammotropes and regressed following their removal. Grafts of these mammary tumors remained dormant in normal hosts for as long as 262 days, growing vigorously after administration of mammotropic hormones.