Simultaneous Activation of Coagulation and Fibrinolysis after Severe Renal Ischemia in Rats

Abstract

Coagulation and fibrinolysis were studied during and after bilateral renal artery occlusion for 2 h in rats. After the release of the arterial clamps platelet count and plasma fibrinogen concentration decreased and circulating fibrin monomers were detected. The shortening of euglobulin lysis time and the accumulation of fibrinogen/fibrin degradation products indicated a simultaneous activation of fibrinolysis. Rapid and severe hemolysis was evident by the steadily increasing plasma hemoglobin concentration. Bilateral nephrectomy reversed all these pathological changes.