Metabolism of 2‐chloro‐N‐isopropylacetanilide (Propachlor) in the rat
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Journal of Environmental Science and Health, Part B
- Vol. 14 (4), 427-441
- https://doi.org/10.1080/03601237909372140
Abstract
Eleven urinary metabolites from [14C]propachlor were either identified or characterized by mass spectrometry. Those identified were 2‐[S‐(N‐acetyl)cysteinyl]‐N‐isopropylacetanilide, 2‐(methylsulfonyl)‐acetanilide, 4'‐hydroxy‐2‐(methylsulfonyl)‐acetanilide, and 4'‐hydroxyacetanilide. Those characterized were N‐(l‐hydroxyisopropyl)‐2‐(methylsulfonyl) acetanilide and its glucuronide, the glucuronides of 4'‐hydroxy‐N‐isopropyl‐2‐(methylsulfonyl)acetanilide, N‐(l‐hydroxyisopropyl) aniline, 4'‐hydroxy‐2‐(methylsulfonyl)acetanilide, and either N‐(1‐hydroxy‐isopropyl) acetanilide or 2‐hydroxy‐N‐isopropylacetanilide.Keywords
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