Activities of Imipenem and Cephalosporins against Clonally Related Strains of Escherichia coli Hyperproducing Chromosomal β-Lactamase and Showing Altered Porin Profiles
Open Access
- 1 September 2000
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 44 (9), 2534-2536
- https://doi.org/10.1128/aac.44.9.2534-2536.2000
Abstract
Forty clonally related clinical isolates of Escherichia coli from hospitalized patients were resistant to cefoxitin (MICs, >256 μg/ml) and ceftazidime (MICs, 32 to 256 μg/ml) and were intermediate or resistant to cefotaxime (MICs, 16 to 128 μg/ml) but susceptible to both cefepime (MICs, 0.5 to 2 μg/ml) and imipenem (MICs, 0.125 to 0.25 μg/ml). Resistance to β-lactams was related to high-level production of AmpC β-lactamase and loss of OmpF porin.Keywords
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