The conversion of cephalosporins to 7 α-methoxycephalosporins by cell-free extracts of Streptomyces clavuligerus
- 15 February 1980
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 186 (2), 613-616
- https://doi.org/10.1042/bj1860613
Abstract
In the presence of S-adenosylmethionine, 2-oxoglutarate, Fe2+ and a reducing agent, cell-free extracts of S. clavuligerus convert cephalosporin C and O-carbamoyldeacetylcephalosporin C into 7.alpha.-methoxy derivatives. No synthesis of a 7.alpha.-methoxy derivative of deacetylcephalosporin C was detected in the system used, and the 7.alpha.-methoxy derivative of deacetoxycephalosporin C was produced only in relatively small amounts. The 7.alpha.-methoxy group is introduced after the cephalosporin ring system has been formed and its introduction may represent the final step in a biosynthetic pathway.This publication has 6 references indexed in Scilit:
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