Thyroxine: Conversion to Triiodothyronine by Isolated Perfused Rat Heart

24 September 1971

journal article
other
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 173 (4003), 1242-1243
https://doi.org/10.1126/science.173.4003.1242

Abstract

Thyroxine labeled with carbon-14 and iodine-125 was perfused through surviving rat hearts. Only when unlabeled triiodothyronine was added as a carrier could the newly formed doubly labeled triiodothyronine be isolated. The fact that this triiodothyronine was labeled with the correct ratio of carbon-14 to iodine-125 indicated that it originated from thyroxine. Approximately 5 percent of the initial carbon-14 radioactivity was found in the recovered triiodothyronine.

Keywords

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