Biochemical Studies in Idiopathic Hypercalcaemia of Infancy

Abstract

Observations have been made on the normal serum citrate level in infancy (1.2-3.5 mg/100 ml) and on the serum citrate level and urinary citrate output in idiopathic hypercalcemia of infancy. It is concluded that in idiopathic hypercalcemia the serum citrate is low in the acute phase of the disease and rises up to or beyond the upper limit on recovery with a subsequent fall to average levels. There is a statistically significant negative correlation between the serum Ca level and the serum citrate level in idiopathic hypercalcemia. The urinary output of citrate is low in the acute phase of the disease rising to normal levels with recovery.