Theophylline‐sensitive modulation of non‐cholinergic excitatory neurotransmission in the guinea‐pig ileum
Open Access
- 1 October 1985
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 86 (2), 315-317
- https://doi.org/10.1111/j.1476-5381.1985.tb08898.x
Abstract
Atropine-resistant longitudinal contractions of the guinea-pig ileum due to field stimulation were greatly augmented by theophylline (150 μM). Adenosine exerted an opposite effect. Theophylline did not potentiate contractions evoked by exogenous substance P. It is suggested that a theophylline-sensitive inhibitory mechanism (possibly mediated by adenosine or a related substance) controls transmitter release from enteric non-cholinergic excitatory neurones.Keywords
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