Immunity of C3H Mice to Lymphosarcoma 6-C3H-Ed Following Regression of the Implanted Tumor

Abstract

Cells of Lymphosarcoma 6-C3H-Ed implanted in C3H mice, in doses which failed to induce tumors when implanted into the tail, in large doses which induced tumors that were destroyed by intermittent occlusion of the blood supply, and by regression of palpable tumors through intensive treatment with amethopterin, led to development of immunity of the mice against subsequent progressive growth of the same tumor.