Identification of a eukaryotic‐like protein kinase gene in Archaebacteria
Open Access
- 1 January 1995
- journal article
- for the-record
- Published by Wiley in Protein Science
- Vol. 4 (1), 126-129
- https://doi.org/10.1002/pro.5560040115
Abstract
Primary sequence patterns based on known conserved sites in eukaryotic protein kinases were used to search for eukaryotic-like protein kinase sequences in a six-frame translation of the bacterial subsection of GenBank. This search identified a previously unrecognized eukaryotic-like protein kinase gene in three related methanogenic archaebacteria, Methanococcus vannielii, M. voltae, and M. thermolithotrophicus. The proposed coding sequences are located in orthologous open reading frames (ORFs): ORF547, ORF294, and ORF114, respectively. The C-terminus of the ORFs contains 9 of the 11 subdomains characteristically conserved within the eukaryotic protein kinase catalytic domain. The N-terminus of the ORFs is similar to a putative glycoprotease in Pasteurella haemolytica and its homologue in Escherichia coli, the orfX gene. This is the first report of a eukaryotic-like protein kinase sequence observed in Archaebacteria.Keywords
This publication has 36 references indexed in Scilit:
- The genetic data environment an expandable GUI for multiple sequence analysisBioinformatics, 1994
- Eukaryotic‐like protein serine/threonine kinases in Myxococcus xanthus, a developmental bacterium exhibiting social behaviorJournal of Cellular Biochemistry, 1993
- Introduction: Protein phosphorylation and signal transduction in bacteriaJournal of Cellular Biochemistry, 1993
- Nucleotide sequence of the genes for ribosomal proteins HS15 and HSH from Haloarcula marismortui: an archaeon‐specific gene clusterFEBS Letters, 1992
- A gene encoding a protein serine/threonine kinase is required for normal development of M. xanthus, a gram-negative bacteriumCell, 1991
- Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein KinaseScience, 1991
- Basic local alignment search toolJournal of Molecular Biology, 1990
- Protein kinases: A diverse family of related proteinsBioEssays, 1987
- CONTROL OF MULTICELLULAR DEVELOPMENT: DICTYOSTELIUM AND MYXOCOCCUSAnnual Review of Genetics, 1986
- Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical featuresBiopolymers, 1983