EFFECTS OF FUNCTIONAL DISTURBANCES OF THE LIMBIC SYSTEM ON THE MEMORY CONSOLIDATION

Abstract

To see the effects of functional disturbances of the limbic system on memory consolidation, several experiments were performed in rats. In part 1, the limbic seizure was produced by hippocampal electrical stimulation 1 min. after a training trial, and the results were compared to Ss with ECS [electroconvulsive shock]. In part 2, KC1 or Ca was injected into reticular formation or hippocampus. The functional disturbances of the hippocampal area had a similar effect as ECS in a passive avoidance. When daily treatments were continued, Ss with ECS showed severe retardation in maze learning. Ss receiving injections in the reticular formation showed more retardation in both maze learning and active avoidance in comparison with Ss receiving hippocampal injection.