DEMYELINATION, or the destruction of the myelin sheath of nerve fibers, is a prominent characteristic of many neurologic disorders. An understanding of the chemical changes associated with demyelination is obviously desirable. A study of these changes is practicable only if there is available a ready means of producing the destruction of "myelin" experimentally. Technics for the production of an experimental demyelination in the central nervous system have been reviewed in papers by Putnam and his colleagues,1 Hurst2 and, more recently, Wolf, Kabat and Bezer.3 More convenient for a chemical study, however, is the well known wallerian degeneration of the distal segment of a cut peripheral nerve. This type of degeneration can be easily produced in the laboratory and has the added advantage that the histologic changes are well understood and have often been described.4 Rarely have the technics of chemistry been applied to degenerating nerves. Notable